Cerebral microbleeds: A clinical issue for cardiologists?

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Cerebral Microbleeds: A Review of Clinical, Genetic, and Neuroimaging Associations

Cerebral microbleeds (microbleeds) are small, punctuate hypointense lesions seen in T2* Gradient-Recall Echo (GRE) and Susceptibility-Weighted (SWI) Magnetic Resonance Imaging (MRI) sequences, corresponding to areas of hemosiderin breakdown products from prior microscopic hemorrhages. They occur in the setting of impaired small vessel integrity, commonly due to either hypertensive vasculopathy ...

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Cerebral Microbleeds: Their Associated Factors, Radiologic Findings, and Clinical Implications

Cerebral microbleeds (CMBs) are tiny, round dark-signal lesions that are most often detected on gradient-echo MR images. CMBs consist of extravasations of blood components through fragile microvascular walls characterized by lipohyalinosis and surrounding macrophages. The prevalence of CMBs in elderly subjects with no history of cerebrovascular disease is around 5%, but is much higher in patien...

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Cerebral microbleeds in a neonatal rat model

BACKGROUND In adult humans, cerebral microbleeds play important roles in neurodegenerative diseases but in neonates, the consequences of cerebral microbleeds are unknown. In rats, a single pro-angiogenic stimulus in utero predisposes to cerebral microbleeds after birth at term, a time when late oligodendrocyte progenitors (pre-oligodendrocytes) dominate in the rat brain. We hypothesized that tw...

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Cerebral microbleeds: histopathological correlation of neuroimaging.

BACKGROUND In recent years, there has been a growing interest in cerebral microbleeds (CMBs) and their role in cerebrovascular disease. A few studies have investigated the histopathological correlation between CMBs and neuroimaging findings. We conducted a systematic review in an attempt to characterize the pathological and radiological correlation. METHODS A systematic literature search was ...

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Prevalence and Risk Factors of Cerebral Microbleeds

Background and Purpose—We previously reported on the high prevalence of cerebral microbleeds (CMBs) in community-dwelling people aged 60 years and older. Moreover, we found that their spatial distribution likely reflects differences in underlying etiology. We have since almost quadrupled the number of participants in our study and expanded it to include persons of 45 years and older. We examine...

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ژورنال

عنوان ژورنال: Archives of Cardiovascular Diseases

سال: 2016

ISSN: 1875-2136

DOI: 10.1016/j.acvd.2016.01.004